بررسی عملکرد زنجیره تامین و توزیع دارو با بهره‌گیری از فناوری بلاکچین بر اساس رویکرد سیستم داینامیک

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه مدیریت صنعتی، دانشکده اقتصاد، مدیریت و علوم اداری، دانشگاه سمنان، سمنان، ایران

2 دانشیار، گروه مدیریت صنعتی، دانشکده اقتصاد، مدیریت و علوم اداری ، دانشگاه سمنان، سمنان، ایران

3 استاد، گروه مدیریت صنعتی، دانشکده اقتصاد، مدیریت و علوم اداری ، دانشگاه سمنان، سمنان، ایران

چکیده
تولید و گردش داروهای تقلبی در زنجیره تأمین دارو، به‌ویژه در حوزه سلامت عمومی، یک چالش جدی و حیاتی به شمار می‌آید. سیستم‌های مدیریت موجود در زنجیره تأمین قادر به تضمین تأمین داروهای اصلی برای بیماران نیستند. به‌منظور ارتقاء اعتبار داروها و کاهش مشکلات زنجیره تأمین، پیشنهاد می‌شود رویکرد مبتنی فناوری بلاک چین استفاده شود. لذا این پژوهش به بررسی عملکرد زنجیره تأمین دارو با استفاده فناوری بلاک چین می‌پردازد ایمنی سلامت عمومی را تضمین کند. جهت پیادهسازی از روش سیستم داینامیک استفاده میشود. پیاده‌سازی موفق فناوری بلاک‌چین نیازمند درک عمیق‌تری از دینامیک‌های پیچیده سیستم تعاملات بین اجزا مختلف آن است. رویکرد سیستم داینامیک می‌تواند به تحلیل این پیچیدگی‌ها و شناسایی اثرات بلندمدت تغییرات در زنجیره تأمین کمک کند. بدین منظور ابتدا داده‌های مورد نظر ادبیات و مصاحبه خبرگان صنعت دارو جمع‌آوری گردید سپس با تعریف متغیرها، طراحی حلقه‌های بازخوردی و نگارش معادلات ریاضی مرتبط، مدل‌سازی صورت گرفته است. در ادامه، نمودارهای علی معلولی و همچنین انباشت جریان ایجاد گردید شبیه‌سازی برای یک دوره یک ساله انجام گرفت. نتایج حاصل از پژوهش نشان که از بین شاخص مورد بررسی شاخص افزایش نرخ ردیابی جلوگیری از تقلب اهمیت ویژه‌ای دارد زیرا سلامت عمومی مستقیماً تحت تأثیر آن قرار دارد دیگر شاخص‌ها ترتیب اهمیت شامل نرخ متعادل‌سازی فرآیند قیمت-گذاری، قراردادهای هوشمند، هویت دیجیتالی هماهنگی نیز به بهبود عملکرد و تقویت اعتماد در این صنعت کمک می‌کنند. به طور کلی این شاخص‌ها به صورت مجموعه‌ای از ابزارهای بلاک چین برای ارتقاء شفافیت، امنیت، کارایی و کاهش تقلب در زنجیره تأمین دارو استفاده می‌شوند.

کلیدواژه‌ها


عنوان مقاله English

Examining the performance of the drug supply and distribution chain using blockchain technology based on the dynamic system approach

نویسندگان English

fereshteh bahrami 1
Azim Zarei 2
Mohsen Shafiei Nikabadi 3
farshid farokhizadeh 1
1 PhD Student, Department of Industrial Management, Faculty of Economics, Management and Administrative Sciences, Semnan University, Semnan, Iran
2 Associate Professor, Department of Industrial Management, Faculty of Economics, Management and Administrative Sciences, Semnan University, Semnan, Iran
3 Professor, Department of Industrial Management, Faculty of Economics, Management and Administrative Sciences, Semnan University, Semnan, Iran
چکیده English

The production and circulation counterfeit drugs in the drug supply chain, especially in the field public health, is serious and vital challenge. Existing management systems in the supply chain are not able to guarantee the supply essential drugs patients. In order improve credibility medicines and reduce the problems the supply chain, it is suggested use the approach based blockchain technology. this research examines the performance the drug supply chain using blockchain technology ensure safety public health. Dynamic system method is used for implementation. The successful implementation blockchain technology requires a deeper understanding the complex dynamics the interaction system between its various components. The dynamic system approach can help analyze these complexities and identify the long-term effects changes in the supply chain. For this purpose, first, the desired data from the literature and interviews drug industry experts were collected, then modeling was done by defining variables, designing feedback loops and writing related mathematical equations. cause and effect diagrams were created as well as flow accumulation and simulation was performed period one year. The results the research show that among investigated indicators, the indicator increasing the detection rate and preventing fraud is particularly important because public health is directly affected by it. Other indicators, in order importance, include the balancing rate the pricing process, smart contracts, identity Digital coordination helps improve performance and strengthen trust in industry. In general, these indicators are used as a set of blockchain tools to improve transparency, security, efficiency and reduce fraud in the drug supply chain.

کلیدواژه‌ها English

blockchain technology
drug supply and distribution chain
dynamic system
[1] Musamih, A., Salah, K., Jayaraman, R., Arshad, J., Debe, M., Al-Hammadi, Y., & Ellahham, S, A blockchain-based approach for drug traceability in healthcare supply chain, IEEE access, (2021), 9, pp. 9728-9743. r 10.1109/ACCESS.2021.3049920 
[2] Dewangan NK, Chauhan RP, Jain N, A New Blockchain-Based Medical Model for Smart Hospital Integrity Management of the Drug Supply Chain, Research Journal of Pharmacy and Technology, (2024), 17(2), pp. 885-92. https://doi.org/10.52711/0974-360X.2024.00137
 [3] Modgil, S.; Singh, R.K.; Hannibal, C, Artificial intelligence for supply chain resilience: Learning from COVID-19, Int. J. Logist. Manag, (2021). https://doi.org/10.1108/IJLM-02-2021-0094
[4] World Health Organization, 1 in 10 medical products in developing countries is substandard or falsified, (2017).
[5] Funding, H. R., 20 Shocking Counterfeit Drugs Statistics, (2017). https://doi.org/10.1186%2Fs13677-022-00341-2
[6] FDA, Drug Supply Chain Security Act (DSCSA), FDA U.S. Food & drug Administration, (2016).
[7] Julsvoll, A. A., & Sickenberger, M, How can Blockchain Technology be used to support Supply Chain Risk Management in Drug Supply Chains? (Master's thesis, Handelshøyskolen BI), (2022).  https://hdl.handle.net/11250/3037318
[8] Sarkar, Shambhu, Digital Traceability of pharmaceutical drugs in supply chain, International Journal of Advance Research in Computer Science and Management, (2022), 10(2) , pp. 39-44. https://www.researchgate.net
 [9] Khezr, S., Moniruzzaman, M., Yassine, A., & Benlamri, R, Blockchain technology in healthcare: A comprehensive review and directions for future research, Applied sciences, (2019), 9(9), p.1736. https://doi.org/10.3390/app9091736
[10] Venhuis BJ, Oostlander AE, Di Giorgio D, Mosimann R, du Plessis I, Oncology drugs in the crosshairs of pharmaceutical crime, The Lancet Oncology, (2018), 1, 19(4):e209-17. https://doi.org/10.1016/s1470-2045(18)30101-3
[11] Agbo, C. C., Mahmoud, Q. H., & Eklund, J. M, Blockchain Technology in Healthcare: A Systematic Review. Healthcare, (2019), 7(2), 56. https://doi.org/10.3390/healthcare7020056
[12] ConsenSys Blockchain in Healthcare and the Life Sciences, ConsenSys , (2021).
[13] Jahanian, S, d, & Hashemi, F, The supply chain paradigm model based on the Internet of Things and Blockchain; a systematic review, New Researches in Decision Making, (2022),  7(3),pp. 171-191. https://dorl.net/dor/20.1001.1.24766291.1401.7.3.7.2.] In Persian[
[14] Drescher, D, Blockchain Basics, A Non-Technical Introduction in 25 Steps; Apress: Frankfurt am Main, Germany,2017) ). DOI 10.1007/978-1-4842-2604-9
[15] San, K.M.; Choy, C.F.; Fung, W.P, The potentials and impacts of blockchain technology in construction industry: A literature review. In IOP Conference Series: Materials Science and Engineering; IOP Publishing: Bristol, UK, (2019), Vol. 495, p. 012005. Doi: 10.1088/1757-899X/495/1/012005
[16] Azizi, N., Malekzadeh, H., Akhavan, P., Haass, O., Saremi, S., & Mirjalili, S, IoT–blockchain: harnessing the power of internet of thing and blockchain for smart supply chain, Sensors, (2021), 21(18), p. 6048. https://doi.org/10.3390/s21186048] In Persian[
[17]Jamil, F., Hang, L., Kim, K., & Kim, D, A novel medical blockchain model for drug supply chain integrity management in a smart hospital, Electronics, (2019), 8(5), p. 505. https://doi.org/10.3390/electronics8050505
[18] Rahimian, Mohammad Mahdi, Rajabzadeh Qatari, Ali, measuring the resilience of the supply chain with the approach of complex adaptive systems; Case study: Iranian pharmaceutical industry, New researches in decision making, (2016), 2(2), pp.  155-195 .] In Persian[
 [19]A. Marucheck, N. Greis, C. Mena, and L. Cai, Product safety and security in the global supply chain: Issues, challenges and research opportunities, J, Oper. Manage., (2019),  vol. 29, nos. 7–8, pp. 707–720, Nov. 2011. http://dx.doi.org/10.1016/j.jom.2011.06.007
[20]Sohan, M., Al, F. A., Khan, S. R., Anannya, N. J., & Ahad, M. T, Towards a secured smart IoT using light weight blockchain: An aim to secure Pharmacy Products, arXiv preprint arXiv, (2022), pp. 2206.06925. https://doi.org/10.48550/arXiv.2206.06925
[21]Mohana, M., Ong, G., & Ern, T, Implementation of pharmaceutical drug traceability using blockchain technology, Inti Journal, (2019), p. 35. https://intijournal.intimal.edu.my/
[22]Abbas, K., Afaq, M., Ahmed Khan, T., & Song, W. C, A blockchain and machine learning-based drug supply chain management and recommendation system for smart pharmaceutical industry, Electronics , (2020), 9(5), p. 852. https://doi.org/10.3390/electronics9050852
[23]Xi, P., Zhang, X., Wang, L., Liu, W., & Peng, S, A review of Blockchain-based secure sharing of healthcare data, Applied Sciences, (2022), 12(15),p.7912. https://doi.org/10.3390/app12157912
[24] Mani, V., Prakash, M., & Lai, W. C, Cloud-based blockchain technology to identify counterfeits, Journal of Cloud Computing, (2022), 11(1), pp.1-15. https://doi.org/10.1186/s13677-022-00341-2
[25] Pillai, M. M. ., Mathur, D. D. ., & Mahdhavi, D. M. , FACTORS INFLUENCING ADOPTION OF BLOCKCHAIN TECHNOLOGY IN THE PHARMACEUTICAL SUPPLY CHAIN FOR PREVENTION OF COUNTERFEIT DRUGS: ENVIRONMENTAL PERSPECTIVE, The Journal of Contemporary Issues in Business and Government, (2022), 28(3), pp.881–889. https://cibgp.com/au/index.php/1323-6903/artic le/view/2422.
[26] Akbar, M. A., Leiva, V., Rafi, S., Qadri, S. F., Mahmood, S., & Alsanad, A, Towards roadmap to implement blockchain in healthcare systems based on a maturity model,  Journal of Software: Evolution and Process, (2022), 34(12), p. 2500.  http://dx.doi.org/10.1002/smr.2500
[27]Uddin, M, Blockchain Medledger: Hyperledger fabric enabled drug traceability system for counterfeit drugs in pharmaceutical industry, International Journal of Pharmaceutics, (2021), 597, p. 120235. http://dx.doi.org/10.1016/j.ijpharm.2021.120235
[28]Fernando, E., & Cassandra, C, Propose Model Blockchain Technology Based Good Manufacturing Practice Model of Pharmacy Industry in Indonesia, In 2021 2nd International Conference on Innovative and Creative Information Technology (ICITech), (2021),  pp. 190-194. IEEE. http://dx.doi.org/10.1109/ICITech50181.2021.9590120
 [29]Ratta, P., Kaur, A., Sharma, S., Shabaz, M., & Dhiman, G, Application of blockchain and internet of things in healthcare and medical sector: applications, challenges, and future perspectives, Journal of Food Quality, (2021), pp. 1-20. https://doi.org/10.1155/2021/7608296
[30]Sabah, S., Hasan, A. T., & Daria, A,   approach to detect counterfeit drugs in medical supply chain, In Proceedings of the International Conference on Big Data, IoT, and Machine Learning: BIM (2021),  pp. 609-621. Singapore: Springer Singapore. http://dx.doi.org/10.1007/978-981-16-6636-0_46
[31]Mackey, T. K., & Cuomo, R. E, An interdisciplinary review of digital technologies to facilitate anti-corruption, transparency and accountability in medicines procurement, Global health action, (2020),  13(sup1), p. 1695241. https://doi.org/10.1080/16549716.2019.1695241
[32] Abbas, K., Afaq, M., Ahmed Khan, T., & Song, W. C, A blockchain and machine learning-based drug supply chain management and recommendation system for smart pharmaceutical industry, Electronics, (2020),  9(5), p. 852. https://doi.org/10.3390/electronics9050852
[33] Mohhamad Ismail, S., and Fatah Zadeh, H., examining the benefits of using blockchain technology in the pharmaceutical supply chain and presenting a conceptual model, the third national conference on interdisciplinary research in management and medical sciences, Tehran, (2022).  http://dx.doi.org/10.1109/ACCESS.2023.3348813] In Persian[
[34]Mohammad Ismail, S., and Fatahzadeh, H, Identifying effective indicators in the use of blockchain technology in the pharmaceutical supply chain (using the metacombination method of 2010-2022), Health Management (Health System), (2021),  12(4 (42)), pp. 81-105. https://doi.org/10.3390/sci5040041] In Persian[
[35]Sepahi, T.a, Shahbazi, M., and Shafii Rudpashti, M., Drug distribution system in Iran: a multi-method study of defects and solutions, Health Image, (2019),  11(4), pp. 324-343. http://dx.doi.org/10.34172/doh.2020.41] In Persian[
[36] ATAEI S., TAGHIPOURIAN M.J., Investigating Factors Influencing on Export Relationship Continuity of Iranian Companies of Medicine Exporter, JOURNAL OF HEALTHCARE MANAGEMENT (JOURNAL OF HEALTH SYSTEM)[Internet], (2019), 10(2 ),pp. 35-47. Available from: https://sid.ir/paper/232383/en] In Persian[
 [37] Hossini Bamkan, M., and Nasiri, E., application of blockchain technology in the field of health and security of the drug supply chain, the fourth international industrial management conference, Yazd, (2018).  http://dx.doi.org/10.1007/978-3-031-43524-9_4] In Persian[
[38]Aslani A., Helo P., and Naaranoja M., Role of renewable energy policies in energy dependency in Finland: System dynamics approach, Applied Energy, (2014), 113, pp. 758-765. DOI: 10.1016/j.apenergy.2013.08.015 
[39] khadivar A, abdian S., Modeling the maturity of green information technology with the system dynamics app roach, ORMR (2018), 8 (2), pp. 73-91 URL: http://ormr.modares.ac.ir/article-28-15887-fa.html] In Persian[
[40]Teodorescu M, Korchagina E., Applying Blockchain in the Modern Supply Chain Management: Its Implication on Open Innovation, Journal of Open Innovation: Technology, Market, and Complexity, (2021), 2 March. https://doi.org/10.3390/joitmc7010080
[41]Abhijith MS, Achuthan, Akash TM,Alan Babu M, Shyam Krishna K., Enhanced Pharmaceutical Supply Chain Management Using Ethereum Blockchain, International Journal of Innovative Science and Research Technology ISSN No:-2456-2165, (2021), Vol. 6, Issue 6, June https://bit.ly/3cMfd3Y
[42]Fernando E, Meyliana M, Warnars HLHS, Abdurachman E & Surjandy S., (a) Blockchain Technology-Based Good Distribution Practice Model of Pharmacy Industry in Indonesia.
Advances in Science, Technology and Engineering Systems Journal, (2021), Vol. 6, No. 2, pp. 267-273. http://dx.doi.org/10.25046/aj060230
[43] Mollik MA. Using Blockchain To Fight Against Counterfeit Medicine, Thesis, Finnish University of Applied Sciences, (2021), https://urn.fi/URN:NBN:fi:amk- 2021053012454. https://doi.org/10.30495/jhm.2022.66173.11031] In Persian[
[44] Ouf, Sh., A Proposed Architecture for Pharmaceutical Supply Chain Based Semantic Blockchain, International Journal of Intelligent Engineering and Systems, (2021), Vol.14, No.3. http://dx.doi.org/10.22266/ijies2021.0630.04
[45]Raxit S, Gourob JH, & Kabir H, A Comprehensive Drug Management  System by Segregating Spurious and Substandard Drugs Using Blockchain Technology, International Conference on Automation, Control and Mechatronics for Industry 4.0 (ACMI), (2021), pp. 1-5. https://doi.org/10.30495/jhm.2022.66173.11031] In Persian[
  [46]Zhang Ch, Pan L, Zhang X, Shen X, Zhang L, Zhang, B & Liu R, Application and prospect of blockchain and smart contract technology in pharmaceutical supply chain, Proc, SPIE 11884, International Symposium on Artificial Intelligence and Robotics, (2021), p. 118840. https://ui.adsabs.harvard.edu/link_gateway/2021SPIE11884E..0CZ/doi:10.1117/12.2601888
[47]Singh Sh, Choudhary G, Shandilya ShK, Sihag V & Choudhary A, Counterfeited Product Identification in a Supply Chain using Blockchain Technology, Research Briefs on Information & Communication Technology Evolution (ReBICTE), (2021), Vol. 7, Article No. 3.  doi:10.22667/ReBiCTE.2021.07.15.003. https://doi.org/10.56801/rebicte.v7i.115
[48] Toloui Ashlaghi, A.,  Radfar, R., Shoja, N.,  and Farkhizadeh, F., measuring the readiness of small and medium manufacturing enterprises to enter e-commerce, Industrial Management Quarterly, Faculty of Human Sciences, Azad University, Sanandaj Branch, (2018), No 47.] In Persian[    
 [49]Sterman, j., System Dynamism, Translated by Shah Golian, K, Tehran: Terme Publishing, (2007). 
[50]Meshaikhi, A., Dynamics of Systems, First Edition, Ariana Qalam Publications, (2017),] In Persian[